Elfituri 2005.

Methods	Randomised controlled trial
Participants	100 healthy Lybian women with a uterus, with natural or surgical menopause, with menopausal symptoms. All had received no previous oestrogen and/or progestogen in preceding 12 months. 1 to 9 years since menopause (mean 2 years). Mean age 44.3 years
Interventions	Tibolone 2.5 mg/d 17beta‐oestradiol 2 mg sequentially combined with dydrogesterone 10 mg For 1 year
Outcomes	Unscheduled bleeding, endometrial cancer, vasomotor symptoms quantified as none (0), mild (1), moderate (2) and severe (3)
Notes	Timing: not reported Location: Lybia Multi‐centre: no; single site
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	No information provided
Allocation concealment (selection bias)	Unclear risk	No information provided
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	No information provided
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Not specified, but given the nature of outcomes assessed, their evaluation is likely to be "objective"
Incomplete outcome data (attrition bias) All outcomes	Low risk	Reasons given for withdrawals/dropouts (2 women)
Selective reporting (reporting bias)	Unclear risk	Study protocol not available
Conflict of interest	Unclear risk	Not reported