Gupta 2013.

Methods	Randomised controlled trial
Participants	100 asymptomatic patients (no menopausal symptoms) with surgical menopause 3 days earlier (total abdominal hysterectomy with bilateral salpingo‐oophorectomy)
Interventions	Tibolone 2.5 mg/d; CEE 0.625 mg; DHEA 25 mg/d (all administered orally); no treatment. Latter 2 arms not considered in the meta‐analysis
Outcomes	Vasomotor symptoms (occurrence of hot flushes and night sweats), insomnia (occurrence), vaginal dryness
Notes	Trial location: India (single centre) Follow‐up: 12 months Timing: 2005
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	No information provided
Allocation concealment (selection bias)	Unclear risk	No information provided
Blinding of participants and personnel (performance bias) All outcomes	High risk	This RCT is presumably an open trial ‐ includes a "no treatment" arm
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	No information provided
Incomplete outcome data (attrition bias) All outcomes	High risk	Study authors acknowledged losses to follow‐up, but total number of lost participants is unclear
Selective reporting (reporting bias)	Unclear risk	Study protocol not available
Conflict of interest	Unclear risk	No information provided