Jacobsen 2012.

Methods	Randomised double‐blind double‐dummy placebo‐controlled trial
Participants	318 community‐living women > 70 years of age
Interventions	Tibolone 1.25 mg/d, placebo, raloxifene 60 mg/d (not considered in the meta‐analysis) for 24 months
Outcomes	Cardiovascular events (TIA; cerebrovascular events; myocardial infarction)
Notes	Trial location: Netherlands (single centre) Timing: July 2003 to Jan 2008
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Block randomisation with computer‐generated list of random numbers
Allocation concealment (selection bias)	Unclear risk	No information provided
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Double‐blind trial; study authors declared that use of double dummy blinded participants
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	No information provided
Incomplete outcome data (attrition bias) All outcomes	High risk	Substantial losses to follow‐up (already > 20% at 3 months)
Selective reporting (reporting bias)	Low risk	Study reported data on outcomes as indicated in the protocol. Additional data on cardiovascular and cerebrovascular events available in the study publication and included in this review
Conflict of interest	Low risk	Sponsored by the Dutch Organization for Health Research and Development. Study authors declare that they have no conflicts of interest