Meeuwsen 2002.

Methods	Randomised placebo‐controlled trial
Participants	85 healthy postmenopausal women, who were ≥ 1 year and at maximum 15 years after natural menopause. Mean age 54.2 years
Interventions	Tibolone 2.5mg/d Placebo Administered for 1 year
Outcomes	Vasomotor symptoms, unscheduled bleeding and sleep
Notes	Timing: not reported Location: Netherlands Multi‐centre: no; single site
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not explained how the randomisation list was generated
Allocation concealment (selection bias)	Unclear risk	Not specified
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Tablets of identical appearance
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Not specified, but given the nature of the outcome assessed, its evaluation is likely to be "objective"
Incomplete outcome data (attrition bias) All outcomes	Low risk	Reasons given for withdrawals (4 women)
Selective reporting (reporting bias)	Unclear risk	Study protocol not available
Conflict of interest	High risk	Drug manufacturer was involved in the trial (random sequence generation was performed by the drug manufacturer)