Wu 2001.

Methods	Randomised controlled trial
Participants	48 healthy postmenopausal women (52 years old), postmenopausal for 12 to 36 months (confirmation by FSH > 40 mIU/mL and oestradiol < 20 pg/mL), with ≥ 1 climacteric symptom according to the Greene Climateric Scale
Interventions	Tibolone 2.5 mg/d 0.625 mg conjugated equine oestrogen and 5 mg medroxyprogesterone acetate (CEE/MPA)/d Administered for 3 months
Outcomes	Menopausal symptoms (assessed using Greene's Climateric Scale), attitudes of sexuality (assessed using McCoy Sex Scale), unscheduled bleeding
Notes	Timing: not clear Not clear if multi‐centre or not
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	High risk	Randomly selected pairs of 2 women were allocated to treatment groups
Allocation concealment (selection bias)	Unclear risk	No information given
Blinding of participants and personnel (performance bias) All outcomes	High risk	Open‐label
Blinding of outcome assessment (detection bias) All outcomes	High risk	Open‐label
Incomplete outcome data (attrition bias) All outcomes	High risk	12/48 dropped out, but reasons given
Selective reporting (reporting bias)	Unclear risk	Study protocol not available
Conflict of interest	High risk	Study sponsored by the manufacturer. Study authors declare that they have no conflicts of interest