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. 2016 Oct 4;2016(10):CD001071. doi: 10.1002/14651858.CD001071.pub3

Bernbaum 1983.

Methods Parallel‐group randomised controlled trial
Participants Participants: 30 preterm infants
Birth weight < 1500 grams (inclusion criteria)
Mean gestational age: 31.5 weeks
Mean postnatal age: 10 days
Setting: the Children's Hospital of Philadelphia, USA.
Inclusion criteria: infants with a birth weight < 1500 grams, with no requirement for surgical intervention, no seizures or CNS haemorrhages, no cardiac or pulmonary diseases and no requirement for further management from the intensive care team at the time nasogastric feeding commenced
Exclusion criteria: premature infants that were small for gestational age
Interventions Experimental group: pacifier during gavage feeding. Sucking opportunities were not allowed between feeding periods. The pacifier which was constructed from an unperforated standard‐sized disposable nipple plugged with the plunger of a 20 mL syringe to prevent swallowing of air. Caregivers manipulated it to encourage sucking and placed it so that it remained in the infant's mouth during the entire feeding. All infants were gavage fed until they attained a weight of 1700 grams, at which time they began oral feedings that increased in frequency and amount according to the infant's tolerance.
Control: no NNS
Sucking opportunities were not allowed between feeding periods in either group.
Outcomes Intraoral negative (sucking) pressures measured via a specially designed nipple that was attached to pressure transducer.
Sucking patterns: classified into two categories:
  1. organized uninterrupted sucks or bursts greater than 3 consecutive sucks;

  2. sporadic sucking described as sucks associated with bursts.


Daily caloric intake
Anthropometric measures (weight, length and head circumference)
Gastrointestinal transit time: determined by the time interval between the nasogastric feed with 125 mg of Carmine red and its appearance in the stools
Frequency of bowel movements
Time taken until first 5 bottle feeds are achieved
Time to reach 2 kg weight
Days for transition from partial to full oral feeds
Length of hospital stay
Notes
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Random envelope assignment (information supplied by author)
Allocation concealment (selection bias) Low risk Blinding of randomisation ‐ yes
Blinding (performance bias and detection bias) 
 All outcomes High risk Blinding of intervention ‐ noBlinding of outcome assessors ‐ not reported
Incomplete outcome data (attrition bias) 
 All outcomes Low risk Complete follow‐up ‐ yes
Selective reporting (reporting bias) Unclear risk We were unable to obtain the study protocol.