Bernbaum 1983.
Methods | Parallel‐group randomised controlled trial | |
Participants |
Participants: 30 preterm infants Birth weight < 1500 grams (inclusion criteria) Mean gestational age: 31.5 weeks Mean postnatal age: 10 days Setting: the Children's Hospital of Philadelphia, USA. Inclusion criteria: infants with a birth weight < 1500 grams, with no requirement for surgical intervention, no seizures or CNS haemorrhages, no cardiac or pulmonary diseases and no requirement for further management from the intensive care team at the time nasogastric feeding commenced Exclusion criteria: premature infants that were small for gestational age |
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Interventions |
Experimental group: pacifier during gavage feeding. Sucking opportunities were not allowed between feeding periods. The pacifier which was constructed from an unperforated standard‐sized disposable nipple plugged with the plunger of a 20 mL syringe to prevent swallowing of air. Caregivers manipulated it to encourage sucking and placed it so that it remained in the infant's mouth during the entire feeding. All infants were gavage fed until they attained a weight of 1700 grams, at which time they began oral feedings that increased in frequency and amount according to the infant's tolerance. Control: no NNS Sucking opportunities were not allowed between feeding periods in either group. |
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Outcomes | Intraoral negative (sucking) pressures measured via a specially designed nipple that was attached to pressure transducer. Sucking patterns: classified into two categories:
Daily caloric intake Anthropometric measures (weight, length and head circumference) Gastrointestinal transit time: determined by the time interval between the nasogastric feed with 125 mg of Carmine red and its appearance in the stools Frequency of bowel movements Time taken until first 5 bottle feeds are achieved Time to reach 2 kg weight Days for transition from partial to full oral feeds Length of hospital stay |
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Notes | — | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Low risk | Random envelope assignment (information supplied by author) |
Allocation concealment (selection bias) | Low risk | Blinding of randomisation ‐ yes |
Blinding (performance bias and detection bias) All outcomes | High risk | Blinding of intervention ‐ noBlinding of outcome assessors ‐ not reported |
Incomplete outcome data (attrition bias) All outcomes | Low risk | Complete follow‐up ‐ yes |
Selective reporting (reporting bias) | Unclear risk | We were unable to obtain the study protocol. |