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. 2016 Oct 4;2016(10):CD001071. doi: 10.1002/14651858.CD001071.pub3

Harding 2014b.

Methods Parallel‐group randomised controlled trial
Participants Participants: 59 preterm infants (intervention groups I and II and control)
Mean birth weight: 1651 grams
Mean gestational age: 31.60 weeks
Mean postnatal age: postnatal age not reported, but infants were included in the study when they started to show oral readiness
Setting: neonatal unit, UK
Inclusion criteria: preterm
Exclusion criteria: congenital disorders, intraventricular haemorrhages grade III or IV, severe respiratory problems or necrotizing enterocolitis
Interventions Experimental group 2: NNS during gavage feeding (n = 20). Parents were encouraged to use a pacifier to elicit 3 sequential sucks and to encourage sequential sucking for a minimum of 5 minutes. Infants received the intervention after they started showing signs of oral readiness. The intervention was provided for a minimum of 3 days until they were taking all of their feeds orally. Description of the pacifier used for the study not provided
Control: no NNS (n = 10)
Outcomes Time taken to achieve full oral feeding
Number of days in hospital
Type of sucking pattern using the Neonatal Oral Motor Schedule (NOMAS)
Average age of gestation for oral feeding
Notes
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Computer‐generated randomisation
Allocation concealment (selection bias) Low risk "A computer generated randomisation assigned infants to one of three groups"
Blinding (performance bias and detection bias) 
 All outcomes High risk "[R]andomized non‐blinded controlled study"
Blinding of intervention ‐ no
Blinding of outcome assessors ‐ no
Incomplete outcome data (attrition bias) 
 All outcomes Low risk A final total of 60 infants were recruited, and 59 infants completed the offered intervention. At 6 months follow‐up, data were gathered on 56 infants.
Selective reporting (reporting bias) Unclear risk Study protocol not obtained