Skip to main content
. 2016 Oct 4;2016(10):CD001071. doi: 10.1002/14651858.CD001071.pub3

Moreira 2014.

Methods Randomised controlled trial
Participants Participants: 40 preterm infants
Mean birth weight: 1256 grams in control group and 1306 grams in NNS stimulation group
Mean gestational age: 29.9 weeks in control group and 30.1 weeks in NNS stimulation group
Setting: neonatal unit, Hospital de Clínicas da Universidade Federal do Paraná, Brazil
Inclusion criteria: birth weight < 1500 grams, gestational age at birth ≤ 32 weeks, 5‐minute Apgar score ≥ 6, clinical (respiratory and haemodynamic) stability on enrolment and during the study, initiation of enteral feeding by oral or nasogastric tube associated or not with parenteral nutrition, and free and informed consent form signed by the parents.
Exclusion criteria: grades III/IV intraventricular haemorrhage, clinical instability on enrolment or during the study, including necrotizing enterocolitis, sepsis, bronchopulmonary dysplasia and other clinical respiratory or haemodynamic instabilities, 5‐minute Apgar ≤ 5, presence of genetic syndromes, neurological disorders, as well as head, neck or central nervous system congenital malformations
Interventions Experimental group: infants received a 10‐minute NNS stimulation with a gloved finger before feeding, 3 times a day, 3 times a week, with the newborn on a supine, semiflexed position receiving perioral and oral stimulation
Control: no NNS
Outcomes Transition time to oral feeds
Notes
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk "Newborns randomly and equally distributed into 2 groups"
Allocation concealment (selection bias) Unclear risk Not reported
Blinding (performance bias and detection bias) 
 All outcomes Unclear risk Blinding of intervention ‐ unclear
 Blinding of outcome assessors ‐ unclear
Incomplete outcome data (attrition bias) 
 All outcomes Low risk Complete follow‐up ‐ yes
Selective reporting (reporting bias) Unclear risk Study protocol not obtained