Figure 4.
Passive membrane properties of IL-mPFC layer 5 pyramidal neurons in tone alone, fear condition and fear extinction groups from the three developmental stages. Passive membrane properties are measured in same neurons described in figures 1–3. A) Passive membrane properties in pre-adolescent group. The fear condition group exhibited significantly lower input resistance (Rin) and membrane time constant tau values compared with the tone alone group. B) Passive membrane properties in adolescent group. The fear condition and fear extinction groups exhibited significantly reduced Rin and sag values compared with the tone alone group. C) Passive membrane properties in adult group. Passive membrane properties remained largely unaffected, with the exception of significantly reduced tau values in the fear condition group. Left panels show example traces for sag response (Scale: 250 ms/1 mV).