Table 3:

Multivariable-adjusted hazard ratios (95% CIs) for CHD and CVD deaths stratified by ASCVD risk, by CAC score group

CAC Score Group	N (%)	Unadjusted HR (95% CI)	Model 1 HR (95% CI)*	Model 2 HR (95% CI)†
CHD death
ASCVD risk <10%
CAC=0	9 (25)	1.0	1.0	1.0
CAC 1–99	9 (25)	1.29 (0.51 – 3.24)	1.33 (0.52 – 3.38)	1.30 (0.52 – 3.30)
CAC 100–399	6 (16.7)	2.38 (0.85 – 6.67)	2.51 (0.87 – 7.23)	2.39 (0.85 – 6.70)
CAC ≥400	12 (33.3)	8.02 (3.38 – 19.05)	8.60 (3.42 – 21.65)	8.11 (3.24 – 20.29)
ASCVD risk ≥10%
CAC=0	9 (5.3)	1.0	1.0	1.0
CAC 1–99	22 (12.9)	1.10 (0.51 – 2.38)	1.05 (0.48 – 2.30)	1.03 (0.47 – 2.24)
CAC 100–399	35 (20.5)	2.02 (0.97 – 4.20)	1.70 (0.80 – 3.61)	1.60 (0.76 – 3.40)
CAC ≥400	105 (61.4)	4.91 (2.49 – 9.68)	3.74 (1.81 – 7.74)	3.36 (1.63 – 6.94)
CVD death
ASCVD risk <10%
CAC=0	25 (28.4)	1.0	1.0	1.0
CAC 1–99	25 (28.4)	1.28 (0.73,2.22)	1.36 (0.76,2.44)	1.32 (0.74,2.36)
CAC 100–399	14 (15.9)	1.99 (1.03,3.83)	2.16 (1.09,4.27)	2.00 (1.01,3.95)
CAC ≥400	24 (27.3)	5.75 (3.27,10.09)	6.46 (3.39,12.32)	5.92 (3.11,11.26)
ASCVD risk ≥10%
CAC=0	17 (5.3)	1.0	1.0	1.0
CAC 1–99	54 (16.8)	1.43 (0.83,2.46)	1.43 (0.83,2.47)	1.4 (0.81,2.43)
CAC 100–399	76 (23.7)	2.33 (1.38,3.94)	2.02 (1.19,3.45)	1.93 (1.13,3.30)
CAC ≥400	174 (54.2)	4.37 (2.66,7.18)	3.52 (2.09,5.90)	3.28 (1.95,5.51)

N (%) represent number of events in each category.

^* Model 1 adjusted for age and sex.

^†Model 2 adjusted for age, sex, hyperlipidemia, smoker, family history of CHD and diabetes.

ASCVD indicates atherosclerotic cardiovascular disease; CAC, coronary artery calcium; CHD, coronary heart disease; CI, confidence interval; CVD, cardiovascular disease; HR, hazard ratio.