Table 4:
Multivariable-adjusted hazard ratios (95% CIs) for CHD and CVD deaths in the SPRINT-like population (age >50 and FRS>15%), by CAC score group
| CAC Score Group | N (%) | Unadjusted HR (95% CI) |
Model 1 HR (95% CI)* |
Model 2 HR (95% CI)† |
|---|---|---|---|---|
| CHD deaths | ||||
| CAC=0 | 6 (5) | 1.0 | 1.0 | 1.0 |
| CAC 1–99 | 11 (9.2) | 1.05 (0.39, 2.85) | 0.76 (0.28, 2.06) | 0.73 (0.27, 1.99) |
| CAC 100–399 | 25 (20.8) | 3.28 (1.34, 8.0) | 1.71 (0.66, 4.41) | 1.57 (0.62, 4.0) |
| CAC ≥400 | 78 (65) | 8.54 (3.71, 19.6) | 3.24 (1.30, 8.07) | 2.86 (1.17, 7.0) |
| CVD deaths | ||||
| CAC=0 | 10 (4.5) | 1.0 | 1.0 | 1.0 |
| CAC 1–99 | 34 (15.3) | 1.96 (0.97, 3.97) | 1.64 (0.81, 3.4) | 1.57 (0.78, 3.2) |
| CAC 100–399 | 49 (22.1) | 3.87 (1.96, 7.65) | 2.55 (1.25, 5.22) | 2.36 (1.16, 4.8) |
| CAC ≥400 | 129 (58.1) | 8.61 (4.51, 16.4) | 4.33 (2.16, 8.65) | 3.95 (1.98, 7.9) |
N (%) represent number of events in each category.
*
Model 1 adjusted for age and sex.
†
Model 2 adjusted for age, sex, hyperlipidemia, smoker, family history of CHD and diabetes.
CAC indicates coronary artery calcium; CHD, coronary heart disease; CI, confidence interval; CVD, cardiovascular disease; FRS, Framingham risk score; HR, hazard ratio; SPRINT, Systolic Blood Pressure Intervention Trial.