Table 1.

Associations of APOL1 with kidney diseases – would this be useful?

Disease	Associations of APOL1 high risk status
HIV-associated nephropathy	OR 29 in USA, OR 89 in South African
Focal segmental glomerulosclerosis	OR 17
Lupus nephritis	Progression to ESKD, OR 2.7 Collapsing glomerulopathy, OR 5.4
Hypertension-attributed nephropathy	Progression to serum creatinine >3, OR 4.6
Diabetes and kidney disease	Progression rate, 1.32 ml/min/yr in APOL1 HR group, 1.07 ml/min/yr in APOL1 LR group

Shown are the OR for carriage of two APOL1 risk alleles for the various conditions shown.