Figure 4.

Heatmap of associations between genera and systolic blood pressure from multivariable-adjusted models. Direction of association is indicated by color (blue: negative, red: positive) and FDR-adjusted p-values (q-values) are indicated by shading (bold: q-value<0.05, light: 0.05≤q-value<1.0). Multivariable-adjusted regression models adjusted for: Model 2: sequencing run, age, race, gender, study center, educational attainment; Model 3: additionally adjusted for smoking, physical activity, diet quality score, and antihypertensive medication use; Model 4: additionally adjusted for BMI. Results are not shown for Model 5, which adjusted for Model 3 covariates plus waist circumference, as Model 5 results were not meaningfully different from Model 4 results.