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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Hypertension. 2019 May;73(5):1120–1127. doi: 10.1161/HYPERTENSIONAHA.118.12454

Table 3:

Vasorelaxation in aorta and SMA in ten-week-old offspring.

Vessel
test		 Paramet
er		 Male Female p-value
CON
(n=7)		 SILD
(n=10)		 CON
(n=7)		 SILD
(n=10)		 Treatment Sex Treatment
* sex
Aorta Ach Emax, % 90.5 ± 2.7 90.1 ± 3.4 92.6 ± 2.2 93.8 ± 2.9 0.90 0.34 0.80
logEC50, M −6.9 ± 0.4 −6.8 ± 0.6 −6.9 ± 0.5 −6.5 ± 0.3 0.61 0.72 0.80
AUC 232 ± 29 247 ± 49 266 ± 27 216 ± 24 0.61 0.98 0.35
Aorta SNP Emax 97.4 ± 1.2 98.3 ± 3.2 90.7 ± 3.4 98.9 ± 2.1 0.12 0.28 0.21
logEC50, M −8.1 ± 0.3 −7.9 ± 0.4 −8.2 ± 0.3 −8.3 ± 0.2 0.84 0.40 0.60
AUC 344 ± 27 351 ± 33 347 ± 25 372 ± 17 0.55 0.66 0.74
SMAAch Emax, % 101.7 ± 6.0 99.3 ± 3.0 103.0 ± 2.3 100.5 ± 0.8 0.48 0.71 0.99
logEC50, M −8.0 ± 0.2 −9.3 ± 0.4 −7.6 ± 0.5 −8.2 ± 0.3 0.01 0.06 0.42
AUC 345 ± 20 449 ± 25 355 ± 35 365 ± 23 0.04 0.19 0.09
SMASNP Emax, % 99.8 ± 0.3 100.0 ± 0.7 100.6 ± 2.8 96.2 ± 3.3 0.38 0.52 0.33
logEC50, M −7.9 ± 0.2 −8.9 ± 0.5 −8.5 ± 0.4 −8.2 ± 0.1 0.31 0.79 0.09
AUC 358 ± 14 415 ± 32 410 ± 25 344 ± 8 0.87 0.71 0.03

Ach, acetylcholine; AUC, area under the curve; CON, control; Emax, maximum relaxation at 10−4.5; logEC50, sensitivity in M; SILD, sildenafil; SMA, third-order (small) mesenteric arteries; SNP, sodium nitroprusside. Mean ± s.e.m.