Table 1.
Baseline patient characteristics by Klotho level.
| Klotho Quartile | ||||||
|---|---|---|---|---|---|---|
| Characteristic | Total N=3555 | 1st (<463.12) N=889 |
2nd (463.12, 564.95) N=889 |
3rd (564.95, 691.45) N=889 |
4th (>691.45) N=888 |
P-trend |
| Demographics | ||||||
| Age (years) | 64.0 (58.0, 70.0) | 65.0 (58.0, 71.0) | 65.0 (58.0, 71.0) | 64.0 (57.0, 70.0) | 63.0 (57.0, 69.0) | <.001 |
| Male sex, n(%) | 2882 (81.1%) | 690 (77.6%) | 708 (79.6%) | 748 (84.1%) | 736 (82.9%) | 0.001 |
| Past Medical History | ||||||
| Hypertension, n(%) | 1587 (44.7%) | 416 (46.8%) | 406 (45.7%) | 366 (41.2%) | 399 (45.0%) | 0.183 |
| Current smoker, n(%) | 530 (14.9%) | 130 (14.6%) | 153 (17.2%) | 132 (14.9%) | 115 (13.0%) | 0.174 |
| Diabetes mellitus, n(%) | 573 (16.1%) | 108 (12.1%) | 116 (13%) | 137 (15.4%) | 212 (23.9%) | <.001 |
| eGFR<60 (mL/min/1.73m2), n(%) | 556 (15.7%) | 177 (20.0%) | 147 (16.6%) | 127 (14.3%) | 105 (11.8%) | <.001 |
| Prior MI, n(%) | 1992 (56.0%) | 464 (52.2%) | 497 (55.9%) | 509 (57.3%) | 522 (58.9%) | 0.004 |
| Prior PCI or CABG, n(%) | 2570 (72.3%) | 658 (74.1%) | 622 (70%) | 637 (71.7%) | 653 (73.6%) | 0.971 |
| Medications | ||||||
| Aspirin/other antiplatelet, n(%) | 3241 (91.2%) | 822 (92.5%) | 809 (91%) | 814 (91.7%) | 796 (89.7%) | 0.077 |
| Beta-blocker, n(%) | 2195 (61.8%) | 569 (64%) | 537 (60.4%) | 519 (58.4%) | 570 (64.3%) | 0.869 |
| Lipid-lowering agent, n(%) | 2553 (71.9%) | 663 (74.7%) | 637 (71.7%) | 621 (69.9%) | 632 (71.3%) | 0.077 |
| Calcium-channel blocker, n(%) | 1194 (33.6%) | 296 (33.3%) | 317 (35.7%) | 299 (33.7%) | 282 (31.8%) | 0.360 |
| Any diuretic, n(%) | 427 (12%) | 118 (13.3%) | 107 (12%) | 95 (10.7%) | 107 (12.1%) | 0.308 |
| Measurements at Enrollment | ||||||
| Weight (kg) | 82.0 (73.0, 93.0) | 81.5 (72.0, 91.0) | 84.0 (75.0, 94.0) | 82.0 (73.0, 93.0) | 84.0 (75.0, 94.0) | <.001 |
| BMI (kg/m2) | 27.8 (25.3, 30.8) | 27.7 (24.9, 30.4) | 28.1 (25.3, 31.2) | 27.8 (25.3, 30.9) | 28.4 (25.8, 31.5) | <.001 |
| SBP (mmHg) | 132.0 (120.0, 144.0) | 132.0 (122.0, 146.0) | 132.0 (120.0, 145.0) | 130.0 (120.0, 142.0) | 130.0 (120.0, 142.0) | 0.045 |
| DBP (mmHg) | 80.0 (70.0, 84.0) | 80.0 (70.0, 84.0) | 80.0 (70.0, 84.0) | 80.0 (70.0, 84.0) | 80.0 (70.0, 86.0) | 0.043 |
| Apo B (mg/dL) | 135.2 (121.3, 152.1) | 137.4 (121.3, 155.6) | 135.6 (122.8, 151.8) | 135.2 (121.8, 151.7) | 134.1 (119.4, 149.8) | 0.953 |
| Apo A (mg/dL) | 105.0 (91.1, 120.5) | 106.4 (91.5, 121.2) | 104.5 (89.9, 119.0) | 105.1 (91.6, 121.8) | 104.5 (91.3, 121.9) | <.001 |
| Ratio Apo B/Apo A | 0.8 (0.6, 0.9) | 0.8 (0.6, 0.9) | 0.8 (0.6, 0.9) | 0.8 (0.7, 0.9) | 0.8 (0.7, 0.9) | 0.007 |
| LV ejection fraction (%) | 57.0 (50.0, 65.0) | 58.0 (52.0, 65.0) | 59.0 (51.0, 65.0) | 58.0 (50.0, 65.0) | 59.5 (50.0, 65.0) | 0.729 |
| UACR (ug/mg) | 8.6 (5.2, 19.6) | 8.6 (5.1, 20.1) | 8.5 (5.4, 17.6) | 8.2 (5.1, 17.0) | 8.9 (5.3, 23.7) | 0.728 |
| hsCRP (mg/L) | 1.7 (0.8, 3.5) | 2.0 (0.9, 4.0) | 1.8 (0.9, 3.6) | 1.5 (0.8, 3.1) | 1.5 (0.7, 3.2) | <.001 |
| NT-proBNP (pg/mL) | 139.0 (71.0, 272.0) | 165.0 (84.0, 333.5) | 140.0 (74.0, 274.0) | 133.0 (67.0, 247.0) | 121.0 (63.0, 237.5) | <.001 |
| TnT (ng/mL) | 0.0 (0.0, 0.0) | 0.006 (0.004, 0.010) | 0.006 (0.004, 0.009) | 0.006 (0.004, 0.009) | 0.006 (0.004, 0.009) | 0.247 |
| Demographics | ||||||
| Age (years) | 64.0 (58.0, 70.0) | 65.0 (58.0, 71.0) | 65.0 (58.0, 71.0) | 64.0 (57.0, 70.0) | 63.0 (57.0, 69.0) | <.001 |
| Male sex, n(%) | 2882 (81.1%) | 690 (77.6%) | 708 (79.6%) | 748 (84.1%) | 736 (82.9%) | 0.001 |
| Past Medical History | ||||||
| Hypertension, n(%) | 1587 (44.7%) | 416 (46.8%) | 406 (45.7%) | 366 (41.2%) | 399 (45.0%) | 0.183 |
| Current smoker, n(%) | 530 (14.9%) | 130 (14.6%) | 153 (17.2%) | 132 (14.9%) | 115 (13.0%) | 0.174 |
| Diabetes mellitus, n(%) | 573 (16.1%) | 108 (12.1%) | 116 (13%) | 137 (15.4%) | 212 (23.9%) | <.001 |
| eGFR<60 (mL/min/1.73m2), n(%) | 556 (15.7%) | 177 (20.0%) | 147 (16.6%) | 127 (14.3%) | 105 (11.8%) | <.001 |
| Prior MI, n(%) | 1992 (56.0%) | 464 (52.2%) | 497 (55.9%) | 509 (57.3%) | 522 (58.9%) | 0.004 |
| Prior PCI or CABG, n(%) | 2570 (72.3%) | 658 (74.1%) | 622 (70%) | 637 (71.7%) | 653 (73.6%) | 0.971 |
| Medications | ||||||
| Aspirin/other antiplatelet, n(%) | 3241 (91.2%) | 822 (92.5%) | 809 (91%) | 814 (91.7%) | 796 (89.7%) | 0.077 |
| Beta-blocker, n(%) | 2195 (61.8%) | 569 (64%) | 537 (60.4%) | 519 (58.4%) | 570 (64.3%) | 0.869 |
| Lipid-lowering agent, n(%) | 2553 (71.9%) | 663 (74.7%) | 637 (71.7%) | 621 (69.9%) | 632 (71.3%) | 0.077 |
| Calcium-channel blocker, n(%) | 1194 (33.6%) | 296 (33.3%) | 317 (35.7%) | 299 (33.7%) | 282 (31.8%) | 0.360 |
| Any diuretic, n(%) | 427 (12%) | 118 (13.3%) | 107 (12%) | 95 (10.7%) | 107 (12.1%) | 0.308 |
| Measurements at Enrollment | ||||||
| Weight (kg) | 82.0 (73.0, 93.0) | 81.5 (72.0, 91.0) | 84.0 (75.0, 94.0) | 82.0 (73.0, 93.0) | 84.0 (75.0, 94.0) | <.001 |
| BMI (kg/m2) | 27.8 (25.3, 30.8) | 27.7 (24.9, 30.4) | 28.1 (25.3, 31.2) | 27.8 (25.3, 30.9) | 28.4 (25.8, 31.5) | <.001 |
| SBP (mmHg) | 132.0 (120.0, 144.0) | 132.0 (122.0, 146.0) | 132.0 (120.0, 145.0) | 130.0 (120.0, 142.0) | 130.0 (120.0, 142.0) | 0.045 |
| DBP (mmHg) | 80.0 (70.0, 84.0) | 80.0 (70.0, 84.0) | 80.0 (70.0, 84.0) | 80.0 (70.0, 84.0) | 80.0 (70.0, 86.0) | 0.043 |
| Apo B (mg/dL) | 135.2 (121.3, 152.1) | 137.4 (121.3, 155.6) | 135.6 (122.8, 151.8) | 135.2 (121.8, 151.7) | 134.1 (119.4, 149.8) | 0.953 |
| Apo A (mg/dL) | 105.0 (91.1, 120.5) | 106.4 (91.5, 121.2) | 104.5 (89.9, 119.0) | 105.1 (91.6, 121.8) | 104.5 (91.3, 121.9) | <.001 |
| Ratio Apo B/Apo A | 0.8 (0.6, 0.9) | 0.8 (0.6, 0.9) | 0.8 (0.6, 0.9) | 0.8 (0.7, 0.9) | 0.8 (0.7, 0.9) | 0.007 |
| LV ejection fraction (%) | 57.0 (50.0, 65.0) | 58.0 (52.0, 65.0) | 59.0 (51.0, 65.0) | 58.0 (50.0, 65.0) | 59.5 (50.0, 65.0) | 0.729 |
| UACR (ug/mg) | 8.6 (5.2, 19.6) | 8.6 (5.1, 20.1) | 8.5 (5.4, 17.6) | 8.2 (5.1, 17.0) | 8.9 (5.3, 23.7) | 0.728 |
| hsCRP (mg/L) | 1.7 (0.8, 3.5) | 2.0 (0.9, 4.0) | 1.8 (0.9, 3.6) | 1.5 (0.8, 3.1) | 1.5 (0.7, 3.2) | <.001 |
| NT-proBNP (pg/mL) | 139.0 (71.0, 272.0) | 165.0 (84.0, 333.5) | 140.0 (74.0, 274.0) | 133.0 (67.0, 247.0) | 121.0 (63.0, 237.5) | <.001 |
| TnT (ng/mL) | 0.0 (0.0, 0.0) | 0.006 (0.004, 0.010) | 0.006 (0.004, 0.009) | 0.006 (0.004, 0.009) | 0.006 (0.004, 0.009) | 0.247 |
Continuous variable presented as median (interquartile range). BMI – body mass index; CABG – coronary artery bypass graft; eGFR – estimated glomerular filtration rate; hsCRP – high sensitivity C-reactive protein; LV – left ventricle; MI – myocardial infarction; NT-proBNP – N-terminal B-type pro-natriuretic peptide; TnT – troponin-T; UACR – urine albumin/creatinine ratio