Table 1.
Baseline participant characteristics of the entire BIOCARD cohort and participants in the analyses; baseline characteristics for participants in the analyses are also stratified by clinical outcome.
| Characteristic | Entire BIOCARD cohort (N=349) | All in analyses (N=300) | Remained Normal (N=231) | Progressed to MCI (N=69) | |||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| N | % | N | % | N | % | N | % | P-value | |
| Gender, female | 201 | 57.6 | 177 | 59.0 | 142 | 61.5 | 75 | 50.7 | 0.111 |
| Ethnicity, Caucasian | 339 | 97.1 | 293 | 97.7 | 228 | 98.7 | 65 | 94.2 | 0.051 |
|
| |||||||||
| Mean | SD | Mean | SD | Mean | SD | Mean | SD | P-value | |
|
| |||||||||
| Age | 57.3 | 10.4 | 57.4 | 10.1 | 55.8 | 9.4 | 62.9 | 10.5 | <.001 |
| Years of Education | 17.9 | 2.4 | 17.1 | 2.4 | 17.2 | 2.3 | 16.6 | 2.4 | 0.077 |
| MMSE score | 29.5 | 0.9 | 29.5 | 0.81 | 29.6 | 0.78 | 29.4 | 0.91 | 0.121 |
| Cognitive composite score | – | 0.06 | 0.64 | 0.17 | 0.63 | −0.33 | 0.53 | <0.001 | |
| HAM-D score | – | 2.2 | 2.8 | 2.2 | 2.8 | 2.2 | 2.7 | 0.963 | |
|
| |||||||||
| N | % | N | % | N | % | P-value | |||
|
| |||||||||
| HAM-D >1 | – | 141 | 47 | 107 | 46.3 | 34 | 49.3 | 0.666 | |
HAM-D = Hamilton depression scale, MCI = Mild cognitive impairment, MMSE = Mini-Mental State Exam, SD = standard deviation. P-values reflect comparisons between clinical outcome groups.