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. 2019 Apr 10;9:5858. doi: 10.1038/s41598-019-42415-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Immunohistochemical localization of telocytes (TCs)/CD34+ stromal cells in the interstitium of the human tongue striated muscle. (A) Hematoxylin and eosin staining demonstrating the normal appearance of the tongue muscle. (B–H) CD34 immunohistochemistry with hematoxylin counterstain. (B,C) A diffuse CD34+ reticular network is evident in the perimysium encasing skeletal muscle bundles (B) and around intramuscular vessels (dashed arrows) and nerves (arrows) (C). Inset: negative control. (D–F) The endomysium is populated by a dense meshwork of CD34+ TCs projecting long and moniliform telopodes in close relationship with skeletal muscle fibers. (G) CD34+ TCs intimately encircle intramuscular arterioles (BV, blood vessels). (H) TCs form an outer sheath (arrows) for intramuscular nerves (NE) and ganglia (asterisk). Scale bar: 200 µm (A), 100 µm (B,C), 50 µm (D–H).