Fig. 4.

Stem cell differentiation. a Representative Σ_s (top), m_f (middle), and D (bottom) maps of human mesenchymal stem cells (left) and osteoblasts (right) with colored region used to show nuclear segmentation. b Box plots showing the distribution of Σ_s, m_f, and D for the stem cells and osteoblasts. We observe different states of chromatin folding and nuclear dynamics comparing hMSCs to osteoblasts. Scale bar is 8 µm. The box within the plot represents the first quartile, median (center line), and third quartile; the whiskers extend to the minimum and maximum values excluding any outliers (1.5x the interquartile range above the third quartile or below the first quartile; outliers not shown). Reported p-values are from two-tailed, heteroscedastic Student’s t-tests