Table 6.
Canonical pathways in ingenuity pathway analysis associated with differentially expressed genes between control and HCA groups.
| Ingenuity Canonical Pathways | −log10(p-value) | Molecules involved in pathways |
|---|---|---|
| Protein Kinase A Signaling | 4.46 | PTEN,PTGS2,PTPRE,DUSP6,MYH10, NFKBIE,PDE4B,ADD2,DUSP2,NFKBID |
| PI3K/AKT Signaling | 3.32 | PTEN,PTGS2,CDKN1A,NFKBIE,NFKBID |
| IL-17A Signaling in Airway Cells | 3.12 | PTEN,CXCL1,NFKBIE,NFKBID |
| MIF-mediated Glucocorticoid Regulation | 3.09 | PTGS2,NFKBIE,NFKBID |
| MIF Regulation of Innate Immunity | 2.83 | PTGS2,NFKBIE,NFKBID |
| iCOS-iCOSL Signaling in T Helper Cells | 2.46 | PTEN,HLA-DQB1,NFKBIE,NFKBID |
| TNFR2 Signaling | 2 | NFKBIE,NFKBID |
| IL-17 Signaling | 1.99 | PTGS2,CXCL1,TIMP1 |
| 4-1BB Signaling in T Lymphocytes | 1.91 | NFKBIE,NFKBID |
| IL-1 Signaling | 1.9 | NFKBIE,IRAK2,NFKBID |
| PPAR Signaling | 1.9 | PTGS2,NFKBIE,NFKBID |
| IL-17A Signaling in Fibroblasts | 1.84 | NFKBIE,NFKBID |
| B Cell Activating Factor Signaling | 1.71 | NFKBIE,NFKBID |
| IL-8 Signaling | 1.7 | HBEGF,PTGS2,CXCL1,IRAK2 |
| p53 Signaling | 1.68 | PTEN,CDKN1A,TNFRSF10B |
| PI3K Signaling in B Lymphocytes | 1.54 | PTEN,NFKBIE,NFKBID |
| Glucocorticoid Receptor Signaling | 1.49 | CCNH,PTGS2,CDKN1A,NFKBIE,NFKBID |
| IL-10 Signaling | 1.29 | NFKBIE,NFKBID |
| T Helper Cell Differentiation | 1.29 | HLA-DQB1,IL23R |