Figure 2.

Network dynamics without noise. (a) Bifurcation diagram of [p53] versus n_DSB. Black and gray dots denote the stable and unstable steady states, respectively. The blue dots denote the maxima and minima of p53 oscillation. The vertical dotted line indicates n_DSB = 175. The red dots denote the oscillation period (right y-axis). (b) Time courses of protein concentrations at n_DSB = 175. [p53] and [Mdm2] denote the total concentration of unphosphorylated and phosphorylated p53 and that of nuclear and cytoplasmic Mdm2, respectively.