Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Apr 10;9:5883. doi: 10.1038/s41598-019-41904-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Influence of cellular heterogeneity on p53 oscillation. (a) Base-10 logarithm of the ratio of the upper (red) or lower (blue) threshold of each parameter admitting p53 oscillation to its default value. The parameter value ranges from 0.1 to 10 times its default value. Parameters are indexed as follows: 0. n_DSB, 1. k_dwip1, 2. k_rwip1, 3. k_dwip1m, 4. k_swip1, 5. k_swip10, 6. k_dmdm2n1, 7. k_dmdm2n0, 8. k_i, 9. k_o, 10. k_dmdm2c, 11. k_rmdm2, 12. k_dmdm2m, 13. k_smdm2, 14. k_smdm20, 15. k_dp53s, 16. k_bdp53p, 17. k_dp53, 18. k_bdp53, 19. k_acp531, 20. k_wip53s, 21. k_rp53, 22. k_dp53m, 23. k_sp53, 24. k_udim, 25. k_dim, 26. k_deatmwip, 27. k_deatm, 28. k_auto, and 29. k_acatm. (b) Percentage of oscillating cells versus S. (c) CV for the amplitude of p53 oscillation when each parameter alone (0–29) or all parameters (All) are perturbed at S = 0.1. The dotted line denotes the estimate of the CV in the latter case. The inset schematically shows the amplitude (H), width at half height (W), period (P) of p53 pulses and the p53-Mdm2 delay (L). (d) CVs for the amplitude, width, period of p53 oscillation and p53-Mdm2 delay versus S. All parameters are perturbed.