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. 2019 Apr 10;9:5883. doi: 10.1038/s41598-019-41904-9

Figure 5.

Figure 5

Influence of extrinsic noise on the variability in oscillations. (a) Time courses of [p53] with the UWN, GWN or CN at D = 0.1 and τ = 45 min. (b,c) Dependence of the CVs of the amplitude, width, and period of p53 pulses and p53-Mdm2 delay on τ at D = 0.1 (b) and D = 0.3 (c). (d) Comparison of the CV of the amplitude when the CN is added to the process of transcription, translation, mRNA degradation, protein degradation alone or together at D = 0.1. The dotted line denotes the estimate for the CV. In each case, 1000 runs of stochastic simulations lasting 3000 min are performed. The axis of τ is on logarithmic scale.