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. 2019 Apr 10;9:5883. doi: 10.1038/s41598-019-41904-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Estimation of the values of D and τ. Contour maps of D versus τ for the amplitude (a), width (b), period (c) and p53-Mdm2 delay (d) in the presence of only colored noise. Blue curves are specified by the values of CVs. The black circles denote the case with D = 0.04 and τ = 10³ min. In each case, 1000 runs of stochastic simulations lasting 3000 min are performed. The axis of τ is on logarithmic scale.