Table 4.

Most significant genes with differential expression in the no weight gain group before and after 3 months of medication

Gene symbol	Base mean before medication	Base mean after medication	Log 2 fold change	Padj	GeneRif annotation
MTRNR2L2	1108.97	41.38	5.37	4.57E−222
LOC100190986	112.72	11.74	3.55	3.05E−48
IDO1	592.70	2.39	1.26	7.77E−36	BMI
ANKRD22	437.44	2.34	1.23	7.92E−28
ADAMTS2	20.24	0.24	−2.06	2.71E−27
CXCL10	208.90	2.54	1.34	2.47E−26
ART3	223.32	2.47	1.30	5.61E−26
DHFR	1808.97	2.57	1.36	4.56E−22
GBP5	19955.17	1.90	0.93	2.58E−21
SERPING1	1107.86	1.93	0.95	5.52E−21

Gene symbol: official symbol; base mean before medication: mean normalized counts from condition A; base mean after medication: mean normalized counts from condition B; log 2 fold change: the logarithm, to basis 2, of the fold change; P_adj: p value adjusted for multiple testing with the Benjamini–Hochberg procedure, which controls false discovery rate; GeneRif annotation: genes including the strings “BMI” or “cholest” in their GeneRIF definition