Table 5.
The best gene-gene interaction models obtained by GMDR.
| Locus no. | Best model | Testing accuracy (%) | CV consistency | p value |
|---|---|---|---|---|
| 1 | TPH2(rs120074175) | 74.91 | 9/10 | <0.001 |
| 2 | TPH2(rs120074175,rs11178997) | 81.18 | 10/10 | <0.001 |
| 3 | TPH2(rs120074175,rs11178997), 5-HT2A(rs7997012) | 81.86 | 10/10 | <0.001 |
| 4 | TPH2(rs4570625,rs120074175,rs11178997), 5-HT2A(rs6311) | 77.10 | 5/10 | <0.001 |
| 5 | TPH2(rs4570625,rs120074175,rs11178997), 5-HT2A(rs7997012, rs6311) | 77.93 | 10/10 | <0.001 |
| 6 | TPH2(rs4570625,rs120074175,rs11178997), 5-HT2A(rs7997012, rs6311,rs6313) | 77.90 | 10/10 | <0.001 |