Table 1.
Expression of genes linked to psoriasis identified through GWAS and associated IL23A Spearman correlation and p-value and fold change increase in lesional skin and p-value.
| Gene | IL23A Spearman correlation | IL23A Spearman P-value | Fold change increase in lesional skin | Fold change increase P-value |
|---|---|---|---|---|
| B3GNT2 | −0.16 | 0.10537 | 1.001155781 | 0.979956721 |
| CARD14 | 0.27 | 0.00682 | 2.389097546 | 1.33E−47 |
| CARM1 | 0.26 | 0.00968 | 1.141422929 | 0.000834388 |
| CDKAL1 | −0.21 | 0.03518 | 0.8683625 | 3.52E−08 |
| CTSG | −0.16 | 0.10656 | 0.655654701 | 4.50E-13 |
| CXCL1 | 0.46 | 1.30E−06 | 83.27818074 | 2.62E−212 |
| CXCL5 | 0.34 | 0.00056 | 26.29025755 | 2.84E−33 |
| CXCR2 | 0.52 | 6.60E−08 | 6.492199066 | 1.40E−239 |
| DDX58 | 0.33 | 0.00092 | 2.797571851 | 1.14E−69 |
| DEFB4A | 0.35 | 0.00034 | 1901.591548 | 2.62E−271 |
| ELANE | −0.0041 | 0.96819 | 0.491347624 | 6.77E−10 |
| FBXL19 | 0.34 | 0.00062 | 1.85489088 | 5.24E−28 |
| GJB2 | 0.48 | 4.30E−07 | 20.36794869 | 0 |
| HLAC | 0.18 | 0.07342 | 1.194566942 | 0.001439986 |
| IFIH1 | 0.42 | 1.40E−05 | 3.162866511 | 7.72E−104 |
| IL12B | 0.29 | 0.00397 | 29.88723345 | 3.40E−57 |
| IL17A | 0.24 | 0.01769 | 439.3348171 | 1.25E−65 |
| IL22 | 0.1 | 0.31571 | 63.88350813 | 3.46E−30 |
| IL23A | 1 | < 2E−16 | 3.760844628 | 8.35E−45 |
| IL36RN | 0.48 | 4.90E−07 | 7.305421524 | 1.16E−230 |
| IL4R | 0.51 | 6.60E−08 | 3.093054089 | 8.95E−181 |
| KLF4 | 0.012 | 0.90338 | 0.667068955 | 3.81E−15 |
| KRT1 | −0.012 | 0.90464 | 1.206311292 | 0.001401592 |
| KRT10 | −0.062 | 0.54239 | 1.110563157 | 0.047606741 |
| KRT14 | 0.22 | 0.02787 | 1.536561931 | 1.27E−11 |
| KRT16 | 0.27 | 0.00767 | 45.90558693 | 0 |
| KRT17 | 0.39 | 6.00E−05 | 4.076992497 | 2.38E−54 |
| KRT37 | 0.3 | 0.00255 | 5.231342887 | 2.43E−46 |
| KRT5 | 0.094 | 0.35243 | 1.303825713 | 1.61E−07 |
| KRT6A | 0.39 | 8.30E−05 | 24.37406248 | 0 |
| KRT6B | 0.29 | 0.00374 | 8.511861588 | 5.34E−107 |
| KRT6C | 0.25 | 0.01245 | 117.818558 | 3.29E−294 |
| LCE3A | 0.39 | 6.50E−05 | 184.4450577 | 6.18E−144 |
| LCE3B | 0.2 | 0.04403 | 67.28771597 | 2.14E−38 |
| LCE3D | 0.31 | 0.00208 | 36.65620978 | 0 |
| MPO | −0.24 | 0.01605 | 1.474609904 | 0.0051495 |
| NFKBIA | 0.31 | 0.00184 | 1.194928571 | 6.14E−07 |
| NOS2 | 0.64 | 1.20E−12 | 45.89643372 | 5.06E−181 |
| NOS3 | −0.024 | 0.81219 | 1.120615697 | 0.065873995 |
| PTPN22 | 0.09 | 0.38043 | 2.512943835 | 2.58E−45 |
| RELB | 0.3 | 0.0023 | 1.63227558 | 3.66E−17 |
| RUNX3 | 0.073 | 0.47497 | 0.879564111 | 0.003653355 |
| SOCS1 | 0.41 | 3.10E−05 | 1.851306719 | 1.98E−17 |
| STAT3 | 0.51 | 6.50E−08 | 2.199106208 | 7.64E−127 |
| STAT5A | 0.012 | 0.90974 | 0.825113995 | 1.27E−08 |
| TNFAIP3 | 0.825113995 | 1.27E−08 | 1.053151539 | 0.237418045 |
| TNFRSF9 | 0.24 | 0.01749 | 6.76780515 | 2.64E−126 |
| TNIP1 | 0.4 | 4.20E−05 | 1.591537669 | 1.52E−33 |
| TRAF3IP2 | 0.28 | 0.00626 | 1.27943256 | 1.21E−23 |
| TYK2 | 0.084 | 0.41131 | 1.10633692 | 0.027521096 |
| UBE2L3 | 0.22 | 0.03143 | 1.247192396 | 1.13E−20 |
| VDR | 0.36 | 0.00025 | 1.010394091 | 0.770645743 |
| VEGFA | 0.092 | 0.36524 | 1.300943308 | 1.11E−08 |
| VEGFB | −0.12 | 0.22006 | 0.640896258 | 1.01E−36 |