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Summary of this study. (A) Pam2CSK4 and TAA induce DC maturation and CTL priming, which induces tumor cell death. (B) However, TLR2 stimulation increases immunosuppressive TAM proliferation. (C) EGT cancels the proliferation and further renders TAM less immuno-suppressive in combination with TLR2/6 ligand. (D) The EGT function in tumor leads to improved functionality of intratumoral CTLs and enhances therapeutic efficacy of the vaccination.
