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. 2019 Apr 10;9:5873. doi: 10.1038/s41598-019-42338-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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SDHB immunohistochemistry of hemangioblastoma. (a) Hemangioblastoma with SDHB immunonegativity shows no immunoexpression in the cytoplasm in the presence of strong granular staining of capillary endothelial cells (internal control). (b) Hemangioblastoma with strong granular cytoplasmic positivity. Hemangioblastoma with a weak-diffuse pattern of SDHB immunoexpression showing mild cytoplasmic (c) and/or nuclear blush staining (d). Bar indicates 100 µm.