TABLE 2.

Hierarchic Cox regression model evaluating risk factors for mortality in sepsis patients^a

Variable	HR	95% CI	P
Step 1, demographic
CRE	1.70	1.25–2.33	0.01
Age (yr)	1.01	1.01–1.02	<0.01
Step 2, comorbidities
CRE	1.58	1.15–2.17	<0.01
Age (yr)	1.01	1.01–1.02	<0.01
HIV	2.27	1.52–3.39	<0.01
Cancer	1.32	1.06–1.66	0.01
Cirrhosis	2.46	1.58–3.82	<0.01
Cardiovascular disease	1.12	0.90–1.40	0.31
Step 3, infection site
CRE	1.58	1.15–2.18	<0.01
Age (yr)	1.02	1.01–1.02	<0.01
HIV	2.41	1.60–3.60	<0.01
Neoplasia	1.30	1.04–1.62	0.02
Cirrhosis	2.25	1.45–3.51	<0.01
Bacteremia	1.44	1.17–1.77	<0.01
Abdominal infections	1.40	1.05–1.86	0.02
Urinary tract infections	0.77	0.56–1.05	0.10
Pulmonary tract infections	1.20	0.95–1.51	0.12
Step 4, sepsis severity
CRE	1.20	0.88–1.67	0.25
Age (yr)	1.01	1.01–1.02	<0.01
HIV	2.06	1.37–3.12	<0.01
Neoplasia	1.02	0.96–1.50	0.10
Cirrhosis	1.79	1.14–2.79	0.01
Abdominal site infection	1.14	0.88–1.47	0.32
Bacteremia	1.11	0.90–1.37	0.32
Septic shock	3.30	2.67–4.08	<0.01
Quick SOFA	1.22	1.08–1.38	<0.01
Step 5, therapy
CRE	1.21	0.88–1.68	0.23
Age (yr)	1.01	1.01–1.02	<0.01
HIV	1.93	1.28–2.90	<0.01
Cirrhosis	1.82	1.17–2.85	<0.01
Septic shock	3.52	2.86–4.34	<0.01
Quick SOFA	1.21	1.07–1.37	<0.01
Appropriate empirical therapy	0.73	0.57–0.93	0.01

^aAbbreviations: HR, hazard ratio; CI, confidence interval; CRE, carbapenem-resistant Enterobacteriaceae.