Table 2.
Changes in ROTEM Parameters according to the Hemodilution
| Reference range | Dilution level |
|||||
|---|---|---|---|---|---|---|
| 0% | 10% | 20% | 40% | P value | ||
| INTEM | ||||||
| CT (s) | 100–240 | 186 ± 24 | 181 ± 32 | 192 ± 27 | 221 ± 31* | 0.003 |
| CFT (s) | 30–110 | 81 ± 14 | 98 ± 13* | 117 ± 23* | 228 ± 57* | < 0.001 |
| α (°) | 70–83 | 74 ± 3 | 71 ± 3* | 67 ± 4* | 54 ± 6* | < 0.001 |
| MCF (mm) | 50–72 | 61 ± 3 | 59 ± 3 | 54 ± 4* | 44 ± 5* | < 0.001 |
| EXTEM | ||||||
| CT (s) | 38–79 | 60 ± 10 | 59 ± 6 | 62 ± 11 | 94 ± 23* | < 0.001 |
| CFT (s) | 34–159 | 90 ± 12 | 109 ± 21* | 137 ± 32* | 221 ± 57* | < 0.001 |
| α (°) | 63–83 | 73 ± 2 | 68 ± 4* | 65 ± 6* | 53 ± 7* | < 0.001 |
| MCF (mm) | 50–72 | 62 ± 3 | 59 ± 5* | 55 ± 6* | 47 ± 5* | < 0.001 |
| FIBTEM | ||||||
| MCF (mm) | 9–25 | 11 ± 2 | 9 ± 3* | 8 ± 2* | 5 ± 2* | < 0.001 |
Values are presented as mean ± SD. ROTEM: rotational thromboelastometry, INTEM: intrinsically activated test of ROTEM assays (activation with phospholipid and ellagic acid), EXTEM: extrinsically activated tests of ROTEM assays (activation with tissue factor), FIBTEM: extrinsically activated tests of ROTEM assays (activation with cytochalasin D followed by tissue factor), CT: clotting time, CFT: clot formation time, α: alpha-angle, MCF: maximum clot firmness.
*
P < 0.017 compared to the 0% value.