Table 1.

Summary of Potentially Therapeutic Molecules That Modulate Nur77

Molecules	Primary effects	Models and cells studied	References
Cytosporone B	Stimulates Nur77 transcriptional activity Up-regulates Nur77 expression Induces Nur77-mediated apoptosis	Human gastric cancer cells Mouse hepatocytes/C57BL/6	11
	Up-regulates Nur77 expression Suppresses lung inflammation and tissue injury	LPS-induced rat lung inflammation	47
	Inhibits suppressive phosphorylation of Nur77 and maintains Nur77 transcriptional activity	Bleomycin-induced murine model of pulmonary fibrosis	59
6-Mercaptopurine	Stimulates Nur77 transcriptional activity	Mouse myoblasts	60
NuBCP-9	Induces apoptosis	Human T lymphocytes Mouse embryonic fibroblasts	62
DIM-C-pPhOCH3 and DIM-C-pPh	Induce Nur77-dependent apoptosis	Human bladder cancer cells	63
DIM-C-pPhOH	Induces Nur77-dependent apoptosis	Human lung cancer cells	15, 69
Shikonin derivatives	Induce Nur77 expression Trigger Nur77-mediated apoptosis	Various cancer cell lines (including lung cancer cells)	64
n-Butylidenephthalide and its derivative	Induce Nur77 expression Trigger Nur77-mediated apoptosis	Various cancer cell lines	65, 66, 67, 68
Celastrol	Targets Nur77 to mitochondria and induces Nur77-dependent mitophagy Suppresses lung inflammation via Nur77	LPS- and D-GalN–induced mouse lung inflammation Mouse embryonic fibroblasts	71
PDNPA	Protects Nur77 from inhibitory phosphorylation and potentiates Nur77's anti-inflammatory functions	LPS-induced murine model of sepsis Mouse macrophages	12

LPS, lipopolysaccharide; PDNPA, n-pentyl 2-[3,5-dihydroxy-2-(1-nonanoyl)-phenyl]acetate.