Table 2.
Association between age and antibodies that inhibit IE adhesion to endothelial receptors
| Receptor | Coefficient (95% CI) | P value* |
|---|---|---|
| Level of anti-adhesion antibodies and age | ||
| CD36 | − 0.03 (− 0.32 to 0.26) | NS |
| Cell. Fibronectin | 0.54 (0.06 to 1.02) | NS |
| ICAM-1 | 0.69 (0.37 to 1.02) | 0.0003 |
| Integrin αvβ3 | 0.08 (− 0.24 to 0.40) | NS |
| Integrin α3β1 | 0.47 (0.18 to 0.76) | 0.01 |
| Integrin α5β1 | 0.13 (− 0.15 to 0.40) | NS |
| JAM-B | 0.23 (− 0.16 to 0.61) | NS |
| Laminin | 0.68 (0.29 to 1.08) | 0.007 |
| PECAM-1 | 0.32 (− 0.03 to 0.68) | NS |
| P-selectin | 0.31 (− 0.01 to 0.64) | NS |
| Breadth of anti-adhesion antibodies and age | ||
| CD36 | − 0.002 (− 0.04 to 0.03) | NS |
| Cell. Fibronectin | 0.035 (0.002 to 0.07) | NS |
| ICAM-1 | 0.037 (0.02 to 0.06) | 0.01 |
| Integrin αvβ3 | − 0.0005 (− 0.02 to 0.02) | NS |
| Integrin α3β1 | 0.015 (− 0.007 to 0.04) | NS |
| Integrin α5β1 | 0.004 (− 0.01 to 0.02) | NS |
| JAM-B | 0.017 (− 003 to 0.04) | NS |
| Laminin | 0.035 (0.02 to 0.05) | 0.004 |
| PECAM-1 | 0.025 (0.003 to 0.050 | NS |
| P-selectin | 0.019 (− 0.005 to 0.04) | NS |
NS not significant
* Holm corrected P value. Models adjusted for hemoglobin type (HbAA, HbAC, HbAS)