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. 2019 Apr 9;15:1744806919836569. doi: 10.1177/1744806919836569

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© The Author(s) 2019

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — Analgesic effects of Cav3 channel blockers on rat neuropathic pain model induced by PSNL. (a) and (b) Time courses of mechanical allodynia and thermal hyperalgesia of sham (n = 6) and PSNL (n = 6) rats over a period of 14 days after operation. (c) and (d) Time courses of mechanical allodynia and thermal hyperalgesia of rat PSNL models treated with NiCl₂ (0.5 µg/h, i.t., n = 6), TTA-A2 (0.35 µg/h, i.t., n = 7), and ascorbic acid (0.5 g/kg, i.p., n = 5). Intrathecal (n = 5) or intraperitoneal (n = 3) injection of saline was used as the control. *p < 0.05, **p < 0.01, ***p < 0.001, compared with the control. PSNL: partial sciatic nerve ligation; PWT: paw withdrawal threshold; PWL: paw withdrawal latency; i.t.: intrathecal injection; i.p.: intraperitoneal injection; TTA-A2: [2-(4-cyclopropylphenyl)-N-((1R)-1-{5-[(2,2,2-trifluoroethyl)oxo]-pyridin-2-yl}ethyl)acetamide].