Table 3.

Outcome domains and measures

	Bassiri -Jahromi et al. 2012 [30]	Lahfa et al. 2013 [31]	Bunyaratavej at al. 2016 [32]	Fraki et al. 1997 [33]	Escalante et al. 2013 [34]	Baran and Tosti 2002 [35]
Clinical improvement	Photographs	Judged by investigator	(Scoring Clinical Index for Onychomycosis (SCIO) score). Decrease in thickness of subungual hyperkeratosis from the original untreated nail
Clinical cure		Judged by investigator (>  90% clinical improvement)	Scoring Clinical Index for onychomycosis (SCIO) score (>  90% clinical improvement)	Visual inspection, investigator judgement (>  90% clinical improvement)	Nail dystrophy, thickness and a photographic record
Mycological cure	Fungal culture	Microscopy and fungal culture	Potassium hydroxide and fungal cultures	Microscopy and fungal culture	Potassium hydroxide and fungal cultures
Complete cure		Mycological cure + clinical cure	Mycological cure + clinical cure
Adverse events	Participant-reported	Investigator assessment of erythema, irritation, pruritus, desquamation, and patient self-reporting of a burning sensation of the skin surrounding the treated nail (4-point scales)			Participant- reported and clinician driven visual inspection	Participant-reported and clinician driven visual inspection