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. 2019 Apr 11;16:83. doi: 10.1186/s12974-019-1476-6

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — CCI induced neuropathic pain and increased the expression of p-ASK1 in the spinal cord of rats. a, b Mechanical allodynia and thermal hyperalgesia were significantly induced after CCI surgery (n = 8). c The expression of p-ASK1 and ASK1 were significantly increased at day 14 after CCI surgery in the spinal cord of rats. The lumbar spinal cords (L1–L6) were collected and analyzed 14 days after the CCI operation (n = 4). A significant difference was revealed following one-way ANOVA (*P < 0.05, **P < 0.01, ***P < 0.001 vs. control; Bonferroni post hoc tests)