Table 4.

Effect of AC on 24 h urine volume and 24 h urinary albumin excretion in each group ($\stackrel{-}{\mathrm{x}}$±SE).

Weeks	NC		DN		DN+M		DN+AC
	24 h UV (ml/24 h)	24 h UAE (μg/24 h)	24 h UV (ml/24 h)	24 h UAE (μg/24 h)	24 h UV (ml/24 h)	24 h UAE (μg/24 h)	24 h UV (ml/24 h)	24 h UAE (μg/24 h)
2 W	4.07±0.51	1.48±0.14	14.06±1.76∗	4.60±0.56∗	12.25±2.14∗	3.97±0.66∗	12.35±1.42∗	4.67±0.68∗
4 W	4.85±0.21	1.94±0.10	20.57±3.06∗	5.25±0.55∗	13.57±1.98∗#	4.49±0.58∗	15.64±2.03∗	4.57±0.36∗
6 W	5.14±0.30	1.54±0.11	23.50±3.18∗	5.80±0.81∗	18.35±2.17∗	4.61±0.37∗	17.56±1.17∗#	4.31±0.21∗#
8 W	4.93±0.43	1.34±0.07	26.00±2.92∗	6.39±0.63∗	18.28±2.27∗#	4.28±0.48∗#	17.06±1.50∗#	3.78±0.41∗#

Note: NC: normal control mice, DN: diabetic nephropathy mice, DN+M: DN mice given 180 mg/kg metformin, and DN+AC: DN mice given 300 mg/kg AC. 24 h UV: 24 h urine volume and 24 h UAE: 24 h urinary albumin excretion. ∗: P<0.05 compared with the NC group; #: P<0.05 compared with the DN group.