Table 3.
Comparison of red blood cell parameters in male and female subjects, stratified according to the level of UA.
| Low UA | Normal UA | High UA | F value | p value | |
|---|---|---|---|---|---|
| Male | n = 374 | n = 4879 | n = 1115 | ||
| Age (years) | 54.56 ± 14.06 | 50.55 ± 16.12 | 47.70 ± 17.45 | 27.711 | <0.001a,b,c |
| BMI (kg/m2) | 22.36 ± 3.15 | 22.49 ± 3.11 | 22.55 ± 3.05 | 0.536 | 0.585 |
| MCH (pg) | 30.65 ± 1.84 | 30.59 ± 1.57 | 30.60 ± 1.65 | 0.204 | 0.815 |
| MCHC (g/l) | 334.32 ± 11.84 | 336.05 ± 11.53 | 337.88 ± 11.44 | 17.101 | <0.001a,b,c |
| MCV (fl) | 91.72 ± 4.98 | 91.09 ± 4.44 | 90.61 ± 4.73 | 9.523 | <0.001a,b,c |
| RDW (%) | 12.93 ± 0.81 | 12.86 ± 0.70 | 12.90 ± 0.71 | 2.998 | 0.049a |
| RBC (1012/l) | 4.35 ± 0.54 | 4.69 ± 0.44 | 4.78 ± 0.45 | 129.763 | <0.001a,b,c |
| Hemoglobin (g/l) | 133.13 ± 15.26 | 143.30 ± 12.46 | 145.81 ± 12.11 | 143.954 | <0.001a,b,c |
| UA (mmol/l) | 0.169 ± 0.031 | 0.320 ± 0.052 | 0.474 ± 0.060 | 5897.909 | <0.001a,b,c |
| Cr (mmol/l) | 80.43 ± 15.04 | 79.19 ± 20.75 | 81.52 ± 32.86 | 4.844 | 0.008b |
| UA/Cr ratio | 2.48 ± 0.64 | 4.17 ± 0.95 | 5.57 ± 1.23 | 108.731 | <0.001a,b,c |
| Female | n = 120 | n = 3736 | n = 535 | ||
| Age (years) | 46.87 ± 14.56 | 49.17 ± 15.77 | 56.46 ± 17.05 | 51.531 | <0.001a,c |
| BMI (kg/m2) | 22.53 ± 2.86 | 22.60 ± 3.10 | 22.47 ± 3.08 | 0.390 | 0.677 |
| MCH (pg) | 30.00 ± 1.49 | 29.92 ± 1.52 | 29.76 ± 1.65 | 2.987 | 0.051 |
| MCHC (g/l) | 331.30 ± 11.28 | 331.07 ± 10.75 | 331.41 ± 13.25 | 0.235 | 0.791 |
| MCV (fl) | 90.59 ± 3.99 | 90.41 ± 4.06 | 89.81 ± 4.00 | 5.335 | 0.005b,c |
| RDW (%) | 12.98 ± 0.87 | 12.91 ± 0.77 | 13.01 ± 0.80 | 4.586 | 0.010c |
| RBC (1012/l) | 4.12 ± 0.31 | 4.24 ± 0.33 | 4.32 ± 0.35 | 24.123 | <0.001a,b,c |
| Hemoglobin (g/l) | 123.37 ± 9.76 | 126.53 ± 9.32 | 128.34 ± 9.71 | 16.390 | <0.001a,b,c |
| UA (mmol/l) | 0.122 ± 0.022 | 0.246 ± 0.045 | 0.389 ± 0.052 | 2848.194 | <0.001a,b,c |
| Cr (mmol/l) | 59.59 ± 12.64 | 60.27 ± 12.27 | 73.42 ± 16.49 | 12.774 | <0.001a,c |
| UA/Cr ratio | 2.33 ± 0.64 | 4.21 ± 1.05 | 5.90 ± 1.99 | 646.919 | <0.001a,b,c |
RDW: red blood cell distribution width; MCH: mean corpuscular hemoglobin; MCHC: mean corpuscular hemoglobin concentration; MCV: mean corpuscular volume; RBC: red blood cell count; Cr: creatinine; UA: uric acid; BMI: body mass index. Low UA: male (UA < 0.202 mmol/l), female (UA < 0.143 mmol/l); normal UA: male (0.417 > UA ≥ 0.202 mmol/l), female (0.339 > UA ≥ 0.143 mmol/l); high UA: male (UA ≥ 0.417 mmol/l), female (UA ≥ 0.339 mmol/l). a p < 0.05 for the difference between low and normal (1-way ANOVA with the LSD post hoc test). b p < 0.05 for the difference between low and high (1-way ANOVA with the LSD post hoc test). c p < 0.05 for the difference between normal and high (1-way ANOVA with the LSD post hoc test).