Table 2.
Electrocardiographic, echocardiographic, and biomarker findings.
| Features at examinations | Family A | Family B | |||||
|---|---|---|---|---|---|---|---|
| I:1 | II:1 | II:2 | II:3 | I:2 | II:1 | II:2 | |
| Latest ECG | |||||||
| LV hypertrophy | + | + | + | + | + (initial ECG) | + (initial ECG) | + |
| Preexcitation | + | + | + | + | + (initial ECG) | + (initial ECG) | + |
| WPW | + | + | + | + | + (initial ECG) | − (initial ECG) | + |
| Pacemaker/ICD | + | + | |||||
|
| |||||||
| Initial echocardiography | |||||||
| EF (%) | 60–65 | 61 | — | 50 | 76.8 | 75 | 73.4 |
| FS (%) | — | 42 | 20.5 | 36.4 | 44 | 35.7 | |
| LVEDD (cm) | 4.72 | 3.7 | — | 3.57 | 3.9 | — | 4.2 |
| LVPWd (cm) (±SD) | 1.05 | 1.1 (+3.9) | — | 0.87 (+2.1) | 1.27 | — | 1.5 |
| IVSD (cm) (±SD) | 1.31 | 1.1 (+3.2) | — | 0.55 (−1.7) | 1.43 | — | 1.7 |
|
| |||||||
| Latest echocardiography | |||||||
| EF (%) | 67 | 65 | 60 | 57 | 61 | 66 | 65 |
| FS (%) | — | 58 | 45 | 39 | 35.2 | 37.9 | — |
| LVEDD (cm) | 4.91 | 3.64 | 4.64 | 4.16 | 4.04 | 3.91 | 4.71 |
| LVPWd (cm) (±SD) | 0.98 | 1.74 (+6.6) | 0.82 (−0.3) | 1.0 (+1.5) | 1.18 | 2.02 (+8.1) | 1.26 |
| IVSD (cm) (±SD) | 1.16 | 1.7 (+4.8) | 0.82 (−0.6) | 1.4 (+3.9) | 1.47 | 2.52 (+12.7) | 1.4 |
|
| |||||||
| Biomarker (initially) | |||||||
| Troponin (ng/L) | <40 | <40 | <40 | <20 | 90 | 4200 | 40 |
| Creatine kinase (U/L) | 131 | 68 | 286 | 103 | 98 | 350 | 125 |
| BNP (ng/L) | 21 | 28 | 14 | 22 | 253 | 16 | <42 |
|
| |||||||
| Biomarker (latest) | |||||||
| Troponin (ng/L) | — | 83 | <20 | <20 | 351 | 528 | 26 |
| Creatine kinase (U/L) | — | 76 | 115 | 81 | 71 | 156 | 147 |
| BNP (ng/L) | — | 234 | 7 | 11 | 55 | 84 | 11 |