Demographic details (mean ± sd). The sample comprised healthy controls (HC) and those with subjective cognitive decline (SCD)). All participants had an MMSE score ≥ 25 and did not exhibit clinically relevant amyloid deposition (i.e., PET negative). [18F] Flutemetamol SUVR, standard uptake value ratios of brain regions prone to early amyloid uptake (Fig. 1); MMSE, mini mental state examination score. Delayed recall, 10-word delayed recall part of the Alzheimer’s disease assessment scale (number of errors out of 10); AQT, a quick test of cognitive speed color-form version (reaction time in seconds); APOE ε4, carriers of 1 or 2 alleles; History, family history of dementia in first degree relatives