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Immunohistochemically stained liver sections for p53 expression detection. (a) Negative (-) or very weak immunohistochemical reaction in normal control. (b) Strong positive immunohistochemical reaction marked by a dense brown colour in the cytoplasm and nucleus of hepatocytes in APAP-administered rats. (c-e) Substantial decrease in the expression of p53 in APAP-administered rats treated with the navel orange peel extract (c), naringin (d), and naringenin (e) (×200).
