Table 2.
Effects of the navel orange peel hydroethanolic extract, naringin, and naringenin on serum ALT, AST, ALP LDH, and GGT activities and albumin and total bilirubin levels in APAP-administered Wistar rats.
| Parameter | ALT (U/l) | AST (U/l) | ALP (U/l) | LDH (U/l) | GGT (U/l) | Albumin (g/dl) | Total bilirubin (mg/dl) |
|---|---|---|---|---|---|---|---|
| Treatments | |||||||
| Normal control | 30.33 ± 0.91 | 66.66 ± 1.542 | 448.00 ± 17.03 | 1776.81 ± 42.56 | 3.50 ± 0.43 | 3.23 ± 0.08 | 0.70 ± 0.05 |
| APAP | 86.16 ± 2.99a | 141.50 ± 2.591a | 757.50 ± 19.53a | 3522.50 ± 98.20a | 9.88 ± 0.32a | 2.71 ± 0.07a | 1.31 ± 0.13a |
| APAP + navel orange peel extract | 33.33 ± 2.27b | 78.83 ± 3.218b | 492.16 ± 23.73b | 1825.01 ± 43.93b | 3.50 ± 0.43b | 3.20 ± 0.07b | 0.72 ± 0.07b |
| APAP + naringin | 34.33 ± 2.09b | 73.83 ± 4.053b | 497.83 ± 27.83b | 1869.80 ± 32.57b | 3.66 ± 0.33b | 3.20 ± 0.09b | 0.73 ± 0.08b |
| APAP + naringenin | 35.50 ± 1.66b | 74.16 ± 3.807b | 483.50 ± 32.51b | 1852.02 ± 29.92b | 2.66 ± 0.33b | 3.23 ± 0.09b | 0.71 ± 0.09b |
Data are expressed as mean ± SE of n = 6. aSignificantly different from the normal value at p < 0.05. bSignificantly different from the APAP value at p < 0.05.