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. 2019 Apr 9;27(2):586–598.e6. doi: 10.1016/j.celrep.2019.03.039

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© 2019 The Author(s)

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

CP506 Epitope Is Different from the Glycan Hole-Recognizing NAbs Identified Previously

(A) Comparison of the mode of CP506 binding to BG505 SOSIP.664 trimer with rabbit antibodies 10A (EMDB: EMD-8312) and 11A (EMDB: EMD-8311), which recognize the 241/289 glycan hole.

(B) Non-reciprocal competition between CP506 Fab and 10A or 11A Fab shown by competition ELISA. Data were generated in duplication with reactions of CP506 Fab repeated at least twice.

(C) The BG505 241 glycan knockin (KI) mutation, S241N, has no effect on virus neutralization sensitivity to CP506 lineage NAbs, while the 289 glycan KI mutation P291S abolishes neutralization sensitivity. Viruses with BG505 T332N background were tested. WT, wild-type. VRC01 is used as control antibody. Data were generated in duplication, with the mean of the percentage of neutralization shown.