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. 2019 Apr 9;27(2):586–598.e6. doi: 10.1016/j.celrep.2019.03.039

Figure 5.

Figure 5

CP506 Lineage Antibody Epitopes on the Env Trimer

(A) Epitopes of the CP506-lineage antibodies, representative bNAbs, and 241/289 glycan hole targeting mAb 10A on the BG505 SOSIP.664 trimer surface (PDB: 4TVP), with a side view of two protomers shown.

(B) Binding site comparison of CP506 to selected bNAbs and 241/289 glycan hole targeting mAb 10A on 3D EM reconstruction in complex with the BG505 SOSIP.664 trimer. To simplify the view, only antibodies bound with one protomer are depicted.