Figure 6.

Prevalence of CP506-like NAb Responses in All Three Guinea Pigs Whose Polyclonal Plasma Possess BG505 Neutralization Capacity in the Same Study

Guinea pig NAbs (from one animal) and week 46 plasma (from three animals) were tested against a panel of BG505 and MG505 mutant viruses. Plasma neutralization profiles are shown as relative titer (percentage) for mutant viruses compared to BG505 T332N WT virus using the following formula: relative neutralization activity = (ID₅₀ mut/ID₅₀ wt) × 100. Relative neutralization titers <50% of the WT virus are highlighted in blue. Acquisition of neutralization sensitivity to MG505 mutant is highlighted in green. NN, no neutralization. Data were generated in duplication, with the mean of relative neutralization activity (plasma) or IC₅₀ titers (mAbs) shown.