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. 2019 Apr 4;74(1):158–172.e9. doi: 10.1016/j.molcel.2019.01.027

Figure 1.

Figure 1

PCF11 Enhances Transcription Termination Genome-wide

(A) Genomic profile of TSC22D1. Gray shading: termination window in control cells (siLUC, black). PCF11 depletion (siPCF11) is depicted in red. For chrRNA-seq and mNET-seq only sense strand is shown; ChIP is not strand specific. In all profiles, numbers in brackets indicate the viewing range (rpm).

(B–D) Metagene analysis of total Pol II ChIP-seq (B), T4ph mNET-seq (C), and CPSF73 ChIP-seq (D) in cells ± siPCF11 on pc genes >5 kb long with PAS separated by >6 kb from the nearest gene on the same strand (n = 8,389).