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. 2019 Apr 4;13:324. doi: 10.3389/fnins.2019.00324

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Copyright © 2019 Ryu, Werginz and Fried.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ON vs. OFF selectivity is preserved during propagation from the retina to V1. (A,C) Raw in vitro response (black) and stimulus waveform (red) from a typical ON and OFF RGC in response to 2-Hz sinusoidal stimulation. (B,D) Raster plot (left) and PSTH (right) for the same cells. The red traces are a single period of the stimulus waveform aligned to showing timing of the responses. (E,G) Raw response (black) and stimulus waveform (red) from a typical L4 ON cell (E) and a typical L2/3 OFF cell (G) in response to 2-Hz sinusoidal stimulation (100 μA). (F,H) Raster plot (left) and PSTH (right) for the same cells. The red traces are a single period of the stimulus waveform aligned to showing timing of the responses. Note that anodal phases appear as upward and cathodal as downward in all panels (Methods).