Table. Most Frequently Detected Variants in Patients With a Personal History of Prostate Cancer.
| Gene | No. of Requisitions | Variants of Uncertain Significance Detected | Positive Variants Detected, n = 674, (%) | Positive Variants per Requisition, %a |
|---|---|---|---|---|
| BRCA2 | 3459 | 75 | 164 (24.3) | 4.74 |
| CHEK2 | 3300 | 71 | 95 (14.1) | 2.88 |
| ATM | 3207 | 160 | 65 (9.6) | 2.03 |
| MUTYH | 2322 | 27 | 55 (8.2) | 2.37 |
| BRCA1 | 3436 | 38 | 43 (6.4) | 1.25 |
| HOXB13 | 2667 | 0 | 30 (4.5) | 1.12 |
| APC | 2345 | 76 | 30 (4.5) | 1.28 |
| MSH2 | 3350 | 48 | 23 (3.4) | 0.69 |
| TP53 | 3329 | 30 | 22 (3.3) | 0.66 |
| PALB2 | 3014 | 42 | 17 (2.5) | 0.56 |
| PMS2 | 3345 | 50 | 18 (2.7) | 0.54 |
| MSH6 | 3346 | 75 | 15 (2.2) | 0.45 |
| NBN | 3145 | 41 | 10 (1.5) | 0.32 |
| RAD50 | 2173 | 40 | 7 (1.0) | 0.32 |
| BRIP1 | 2461 | 36 | 7 (1.0) | 0.28 |
| RAD51C | 2438 | 21 | 5 (0.7) | 0.21 |
| RAD51D | 2689 | 12 | 4 (0.6) | 0.15 |
| CDKN2A | 2277 | 6 | 3 (0.4) | 0.13 |
| CDH1 | 2504 | 28 | 3 (0.4) | 0.12 |
| NF1 | 2347 | 35 | 2 (0.3) | 0.09 |
| MLH1 | 3343 | 25 | 2 (0.3) | 0.06 |
a
Percentages of positive variants per total gene requisitions are calculated as the number of positive variants in a gene divided by the total number of requisitions for that gene.