Figure 2. Local Regrowth and Rectal Preservation in the Watch-and-Wait Cohort.

At 5 years, the rate of local regrowth was 21%. After a median follow-up of 33 months from the end of neoadjuvant therapy, 22 of the 113 patients (19.5%) included in the watch-and-wait group developed a local regrowth, which corresponds to a 5-year actuarial rate of 21.4% (95% CI, 12%-30%) and thus an organ preservation rate of 79% (95% CI, 70%-88%).