Table 2. Relevant Clinical Characteristics of Patients With Local Regrowth and Subsequent Salvage Surgery.
| Patient | Pattern of Regrowth | Salvage Operation | Height From AV, cm | Initial Clinical Staginga | Surgical Pathology Staginga | CRM | Pelvic Recurrence | Distant Metastases | Disease Status |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Extraluminal | LAR | 6.0 | cT3N2 | ypT3N0 | Negative | No | No | NED |
| 2 | Endoluminal | LAR | 6.5 | cT2N0 | ypT2N0 | Negative | No | No | NED |
| 3 | Endoluminal | LAR | 6.0 | cT3N1 | ypT2N0 | Negative | No | No | NED |
| 4 | Endoluminal | LAR | 4.0 | cT2N0 | ypT3N0 | Negative | No | Yes (lung) | AWD |
| 5 | Endoluminal | LAR | 6.5 | cT3N0 | ypT1N0 | Negative | No | No | NED |
| 6 | Endoluminal | TAE | 10.0 | cT3N1 | NAb | NA | No | Yes (liver, SBRT) | DOC |
| 7 | Endoluminal | LAR | 12.0 | cT3N1 | ypT3N0 | Negative | No | Yes (liver) | DOD |
| 8 | Endoluminal | PRc | 5.0 | cT3N0 | ypT2N0 | Negative | No | Yes (lung/liver) | DOD |
| 9 | Endoluminal | APR | 7.5 | cT2N1 | ypT2N0 | Negative | No | No | NED |
| 10 | Endoluminal | APR | 5.5 | cT3N1 | ypT2N0 | Negative | No | No | NED |
| 11 | Extraluminal | APR | 4.0 | cT3N1 | ypT3N0 | Negative | No | No | NED |
| 12 | Extraluminal | LAR | 7.0 | cT3N1 | ypT3N1 | Negative | No | No | NED |
| 13 | Endoluminal | APR | 7.0 | cT3N0 | ypT2N0 | Negative | No | Yes (lung)d | NED |
| 14 | Endoluminal | APR | 8.0 | cT3N0 | ypT3N1 | Negative | Yes | Yes (lung/liver) | DOD |
| 15 | Endoluminal | APR | 0.5 | cT2N0 | ypT3N0 | Negative | No | Yes (lung) | DOD |
| 16 | Endoluminal | LAR | 10.0 | cT3N1 | ypT3N0 | Negative | No | No | NED |
| 17 | Endoluminal | APRc | 3.0 | cT2N0 | ypT2N2 | Positive | Yes | Yes (lung) | DOD |
| 18 | Endoluminal | APR | 5.0 | cT3N0 | ypT3N0 | Negative | No | No | NED |
| 19 | Endoluminal | LAR | 5.5 | cT3N1 | ypT2N0 | Negative | No | No | NED |
| 20 | Endoluminal | TAE | 5.0 | cT3N0 | ypT1Nx | NA | No | No | NED |
| 21 | Endoluminal | APR | 4.0 | cT3N1 | ypT2N0 | Negative | No | No | NED |
| 22 | Endoluminal | APR | 5.0 | cT3N0 | ypT3N0 | Negative | No | No | NED |
Abbreviations: APR, abdominoperineal resection; AV, anal verge; AWD, alive with disease; CRM, circumferential resection margin; DOC, died of other causes; DOD, died of disease; LAR, low anterior resection; NA, not applicable; NED, no evidence of disease; PR, perineal resection; SBRT, stereotactic body radiation therapy; TAE, transanal excision.
a
According to the 7th edition of the American Joint Committee on Cancer TNM staging system.
b
Patient underwent a salvage procedure at an outside hospital, and the pathology report was not available.
c
Patient initially underwent transanal excision and subsequently required radical resection for salvage.
d
Patient developed lung metastasis and underwent resection; now NED.