Table. Demographic Characteristics and Clinical and APOE Allele Frequencies Across Participating Studies.
| Source | No. (%) | |||
|---|---|---|---|---|
| ERICH (n = 5017) | GOCHA (n = 2297) | ISGC Europe (n = 3471) | GERFHS (n = 2339) | |
| Male sex | 2866 (57.1) | 1266 (55.1) | 1891 (54.6) | 1130 (48.3) |
| Age, median (IQR) | 61 (52-72) | 73 (65-80) | 70 (61-77) | 65 (51-75) |
| Cases | 2880 (57.4) | 1322 (57.6) | 1281 (36.9) | 811 (34.7) |
| Lobar ICH | 882 (30.6) | 613 (47.8) | 493 (40.2) | 316 (39.0) |
| Nonlobar ICH | 1998 (69.4) | 670 (52.2) | 734 (59.8) | 495 (61.0) |
| Hypertension | 3364/4976 (67.6) | 1667/2275 (73.3) | 1673/2893 (57.8) | 1264/2337 (54.1) |
| Self-reported race/ethnicity | ||||
| White | 1739 (34.7) | 2024 (88.1) | 2622 (75.5) | 1949 (83.3) |
| Black | 1751 (34.9) | 131 (5.7) | NA | 390 (16.7) |
| Hispanic | 1527 (30.4) | 60 (2.6) | 194 (5.6) | NA |
| Other/missing | NA | 82 (3.6) | 654 (18.8) | NA |
| APOE ε4 allele count | ||||
| 0 | 3553 (70.8) | 1664 (71.8) | 2789 (80.4) | 1664 (71.1) |
| 1 | 1298 (25.9) | 570 (24.8) | 637 (18.4) | 601 (25.7) |
| 2 | 166 (3.3) | 77 (3.4) | 45 (1.3) | 74 (3.2) |
| APOE ε2 allele count | ||||
| 0 | 4262 (85.0) | 1916 (83.4) | 3034 (87.4) | 1881 (80.4) |
| 1 | 710 (14.2) | 363 (15.8) | 413 (11.9) | 431(18.4) |
| 2 | 45 (0.9) | 18 (0.8) | 24 (0.7) | 27 (1.2) |
Abbreviations: APOE, apolipoprotein E; ERICH, Ethnic/Racial Variations of Intracerebral Hemorrhage; GERFHS, Genetic and Environmental Risk Factors for Hemorrhagic Stroke; GOCHA, Genetics of Cerebral Hemorrhage with Anticoagulation; ICH, intracerebral hemorrhage; IQR, interquartile range; ISGC, International Stroke Genetics Consortium; NA, not applicable.